Mudhoney - Touch Me I'm Sick (1988)
Vocalist Mark Arm is often credited as the first person to call the music that was coming out of Seattle "Grunge". This song is a pretty clear indication of where that came from. The song is growling vocals and distorted guitars. Sure there's a bass line and drums holding the shrieking swaying mass together, but mostly it's a repeated guitar riff on two heavily distorted guitars and a shouted vocal about diseases and rot. The and a half minutes, three chords and anger; like Punk but with more fuzz on the guitar.